abstract：:Immune checkpoints are known to contribute to tumor progression by enhancing cancer's ability to evade the immune system and metastasize. Immunotherapies, including monoclonal antibodies, have been developed to target specific immunosuppressive molecules on the membranes of cancer cells and have proven revolutionary i...

journal_title：American journal of translational research

authors： Smith WM,Purvis IJ,Bomstad CN,Labak CM,Velpula KK,Tsung AJ,Regan JN,Venkataraman S,Vibhakar R,Asuthkar S

更新日期：2019-02-15 00:00:00

abstract：:Berberine (BBR), derived from Huanglian (Coptis chinensis), is a traditional Chinese herbal medicine. In the current study, we investigated the effects of BBR in high glucose (HG) and hypoxia-induced apoptosis with normal rat renal tubular epithelial (NRK-52E) and human kidney proximal tubular cells (HK-2) and further...

journal_title：American journal of translational research

authors： Zhang X,Guan T,Yang B,Chi Z,Wan Q,Gu HF

更新日期：2019-02-15 00:00:00

abstract：BACKGROUND:Gastric cancer (GC) is one of the most common digestive tract tumors, and a serious threat to human health. Long non-coding RNA (lncRNA) are involved in many cancers. However, the biological functions of most lncRNAs are unclear. In this study, we investigated the mechanisms by which FLVCR1-AS1 regulated GC ...

journal_title：American journal of translational research

authors： Liu Y,Guo G,Zhong Z,Sun L,Liao L,Wang X,Cao Q,Chen H

更新日期：2019-02-15 00:00:00

abstract：BACKGROUND:Nasopharyngeal carcinoma (NPC) is a kind of head-neck malignant neoplasm originated from the nasopharyngeal epithelium and is mainly prevalent in Southern China and Southeast Asia countries. KiSS-1 is an inhibitor of tumor metastasis in a range of cancers. METHODS:We establish a cell substrain of SUNE-1-5-8...

journal_title：American journal of translational research

authors： Wang GM,Liu JF,Zhang L,Sun Q,Zhou Y,Xu HB,Zhang YJ,Cai F,Cheng ZN,Xiang P,Jiang H

更新日期：2019-02-15 00:00:00

abstract：:RAB18, a member of the Ras family, has been suggested to play a critical role in multiple biological process. However, its functions in the development of hepatocellular carcinoma (HCC) remain unknown. In the present study, the expression and biological role of RAB18 in HCC were investigated. Results showed that the e...

journal_title：American journal of translational research

authors： Gong T,Zhou B,Liu M,Chen X,Huang S,Xu Y,Luo R,Chen Z

更新日期：2019-02-15 00:00:00

abstract：:Current knowledge of normal developmental physiology and identification of specific cell types of the kidney at molecular levels enables us to generate various cells of the kidney. The generation of renal specialized cells in vitro with its correct molecular and functional implications is the urgent need for cellular ...

journal_title：American journal of translational research

authors： Begum S

更新日期：2019-02-15 00:00:00

abstract：:We tested the hypothesis that adipose-derived fresh stromal vascular fraction (SVF) is non-inferior to conventional adipose-derived mesenchymal stem cell (ADMSC) therapy for improving left-ventricular ejection fraction (LVEF) in rat after acute myocardial infarction (AMI). Male-adult SD rats (n = 48) were categorized ...

journal_title：American journal of translational research

authors： Sheu JJ,Lee MS,Wallace CG,Chen KH,Sung PH,Chua S,Lee FY,Chung SY,Chen YL,Li YC,Yip HK

更新日期：2019-01-15 00:00:00

abstract：:Computed tomography imaging of the temporomandibular joint was carried out in 22 previously-diagnosed arthritis patients (3 men, 19 women). This descriptive, cross-sectional observational, qualitative study allowed to characterize the type of condylar morphology condition, the space between temporomandibular joint, th...

journal_title：American journal of translational research

authors： Mendiburu-Zavala C,Camargo-Riqué ME,Peñaloza-Cuevas R,Cárdenas-Erosa R,Lara-Flores M,Castaño VM

更新日期：2019-01-15 00:00:00

abstract：:Xp11.2 translocation/transcription factor E3 (TFE3) gene fusion renal cell carcinoma (Xp11.2 translocation RCC) was first classified as a distinct type of renal tumor by the World Health Organization in 2004. However, its morphology and clinical manifestations often overlap with those of conventional RCCs. Moreover, a...

journal_title：American journal of translational research

authors： Xu ZY,Wang JP,Zhang Y,Wu SW,Ma L,Qin YZ,Wang ZP,Chai DM,Tao YS

更新日期：2019-01-15 00:00:00

abstract：:Distant metastasis is the main cause of death for non-small cell lung cancer (NSCLC) patients, with the bone as a more frequent metastatic site. The expression of various chemokines and their receptors may contribute to the predilection of organ specific metastasis. In this study, we demonstrated that CC chemokine lig...

journal_title：American journal of translational research

authors： Han S,Wang T,Chen Y,Han Z,Guo L,Wu Z,Yan W,Wei H,Liu T,Zhao J,Zhou W,Yang X,Xiao J

更新日期：2019-01-15 00:00:00

abstract：BACKGROUND:Nasopharyngeal carcinoma (NPC) is a highly invasive malignancy which has unique characteristics when found among individuals from certain ethnic or geographic populations. The role and molecular mechanism of Polo-like kinase 1 (PLK1) in NPC remain yet to be clarified. Hence, the aim of this study is to ident...

journal_title：American journal of translational research

authors： Yang X,Mo W,Fang Y,Wei G,Wei M,Dang Y,Chen G,Hu K,Wei D

更新日期：2018-12-15 00:00:00

abstract：:Background: Pericardial patches are frequently used in vascular surgery to close arteriotomies. The early healing of these patches is mediated by attraction of CD34 and ephrinB2-positive cells. Atorvastatin is a commonly used statin drug that promotes healing of cardiovascular injury. We hypothesized that atorvastatin...

journal_title：American journal of translational research

authors： Li X,Dardik A,Guo R,Zhang W,Xiang Y,Li S,Liu D,Shu C

更新日期：2018-12-15 00:00:00

abstract：:Myoblasts characterize by the potential to transform into skeletal muscle, and involve in processes of proliferation, differentiation and apoptosis. Mammalian target of rapamycin (mTOR) is an important protein of PI3K signaling pathway in muscle metabolism and physiology. This study aimed to investigate effects of mTO...

journal_title：American journal of translational research

authors： Wang M,Mou Y,Da Y,Yuan X,Yan F,Lan W,Zhang F

更新日期：2018-12-15 00:00:00

abstract：:Intrauterine adhesion (IUA) is a common disease among women after uterus operation. BMSCs are commonly used as a therapeutic agent for IUA treatment, but the underlying mechanism is not fully delineated. Here we showed that BMSCs co-cultured with EPCs promotes proliferative ability and decreases apoptosis ratio of BMS...

journal_title：American journal of translational research

authors： Yu J,Jiang L,Gao Y,Sun Q,Liu B,Hu Y,Han X

更新日期：2018-12-15 00:00:00

abstract：:[This corrects the article on p. 2068 in vol. 10, PMID: 30093944.]. ...

journal_title：American journal of translational research

authors： Su ZX,Shi YQ,Lu ZY,Li RL,Wang XL,Ning BB,Duan JL,Hao LS,Duan JH,Li Y,Zhu YJ,Hao CN,Wang R

更新日期：2018-12-15 00:00:00

abstract：:Organ transplantation is often the only effective treatment for patients with end-stage diseases, such as heart, liver, kidney and small bowel failure and is carried out frequently worldwide. Still the post-transplantation complications remain health- and life-threatening outcome that needed to be resolved. With the r...

journal_title：American journal of translational research

authors： Xiao J,Peng Z,Liao Y,Sun H,Chen W,Chen X,Wei Z,Yang C,Nüssler AK,Liu J,Yang W

更新日期：2018-11-15 00:00:00

abstract：:This article aims to explore whether Wharton's jelly (WJ) derived mesenchymal stem cells (MSCs) (WJ-MSCs) decellularized extracellular matrix (dECM) can rejuvenate MSCs during in vitro expansion. Passage 10 synovium-derived mesenchymal stem cells (SDSCs) and WJ-MSCs were expanded on plastic flasks (PL) or dECMs derive...

journal_title：American journal of translational research

authors： Wang Y,Jiang C,Cong S,Guo C,Yan Z

更新日期：2018-11-15 00:00:00

abstract：:Liver cancer, one of the most common malignant tumors occurred worldwide, has emerged as a main health trouble and accounts for leading cancer-related death. Diosgenin is provided as an important material in the pharmaceutical industry, and is used to manage various medical troubles such as cancer because of its multi...

journal_title：American journal of translational research

authors： Yu H,Liu Y,Niu C,Cheng Y

更新日期：2018-11-15 00:00:00

abstract：:Colorectal cancer (CRC) is the third most commonly diagnosed cancer in the world. RING finger-related E3 ubiquitin ligases play a role in tumorigenesis and can function either as oncogenes or tumor suppressors based on their target proteins. Here, we show that the expression of RNF152, a ring finger protein, in CRC ti...

journal_title：American journal of translational research

authors： Cui X,Shen W,Wang G,Huang Z,Wen D,Yang Y,Liu Y,Cui L

更新日期：2018-11-15 00:00:00

abstract：:This study sought to determine the effect and explore the mechanism of the Chinese medicinal compound preparation Diwu Yanggan (DWYG) capsule on the occurrence and development of liver cancer using the Solt-Farber rat model. Sprague-Dawley rats were randomly distributed into a normal group, sham group, DWYG group, sor...

journal_title：American journal of translational research

authors： Ye Z,Gao X,Zhao B,Li H,Wan M,Wu N,Chang M,Cheng S

更新日期：2018-11-15 00:00:00

abstract：:This study tested whether inducible pluripotent stem cell (iPSC)-derived mesenchymal stem cell (MSC) therapy could effectively protect kidney from acute ischemia (1 h) - reperfusion (5 day) injury (IRI). Male-adult SD-rats (n = 24) were equally categorized into groups 1 (sham-control), 2 [sham-control + iPSC-MSC (1.2 ...

journal_title：American journal of translational research

authors： Ko SF,Chen YT,Wallace CG,Chen KH,Sung PH,Cheng BC,Huang TH,Chen YL,Li YC,Chang HW,Lee MS,Yang CC,Yip HK

更新日期：2018-10-15 00:00:00

abstract：:Postoperative fever is prevalent in many breast cancer patients. Some retrospective studies proposed that postoperative fever might also be considered as a rapid rough indicator for the poor prognosis of breast cancer patients. This study aims to explore the possible molecular mechanisms underlying the relapse of brea...

journal_title：American journal of translational research

authors： Li Z,Xu L,Liu Y,Fu S,Tu J,Hu Y,Xiong Q

更新日期：2018-10-15 00:00:00

abstract：BACKGROUND:Glioma is the most common malignant tumor in the adult human brain and has one of the lowest patient survival rates. MicroRNAs (miRNAs) play important roles in the development of cancers, including glioma, and potentially have valuable therapeutic applications in glioma; however, their specific functions and...

journal_title：American journal of translational research

authors： Gu X,Gong H,Shen L,Gu Q

更新日期：2018-09-15 00:00:00

abstract：:Acquired resistance to chemotherapy is a major limitation for the successful treatment of lung cancer. Previously, we and others showed that formation of tumor spheres is associated with chemotherapy resistance in lung cancer cells, but the underlying mechanisms remained largely unknown. In the current study, we show ...

journal_title：American journal of translational research

authors： Chen SS,Tu XY,Xie LX,Xiong LP,Song J,Ye XQ

更新日期：2018-09-15 00:00:00

abstract：:Using a rabbit model of early-stage osteoarthritis (OA) and a sampling patients with OA, we evaluated the diagnostic utility of a fluorogenic peptide-conjugated gold nanoparticle (AuNP) probe in detecting mild cartilage injury, based on the a disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4) en...

journal_title：American journal of translational research

authors： Liu Z,Hu X,Yang P,Zhang J,Zhou C,Ao Y

更新日期：2018-08-15 00:00:00

abstract：:The current study aims to measure distance parameters in lumbar isthmus to develop new references for lumbar pedicle screw insertion. Using computed radiography, the distance between the median pedicle tangent and the isthmus lateral tangent (D1) and the isometric distance between the isthmus lateral tangent and the i...

journal_title：American journal of translational research

authors： Rexiti P,Abudurexiti T,Abuduwali N,Wang S,Sheng W

更新日期：2018-08-15 00:00:00

abstract：:The miR-200 family suppresses epithelial-mesenchymal transition by inhibiting ZEB1 and ZEB2 mRNA translation in several types of cancers. Kindlin-2 is a target gene of miR-200b and its expression level correlates positively to ZEB2 in oral squamous cell carcinoma (OSCC). Whether Kindlin-2 and ZEB2 share a competitive ...

journal_title：American journal of translational research

authors： Ren W,Gao L,Qiang C,Li S,Zheng J,Wang Q,Zhi Y,Cai G,Kong X,Zhou M,Qu Z,Zhi K

更新日期：2018-08-15 00:00:00

abstract：:Growing evidence has revealed that the initiation of various malignancies is closely associated with alternative splicing (AS) events in certain key oncogenes. However, in diffuse large B-cell lymphoma (DLBCL), there is still a great deal to learn about AS variants. In this study, 33,724 AS variant profiles were obtai...

journal_title：American journal of translational research

authors： Zhang R,Lin P,Yang X,He RQ,Wu HY,Dang YW,Gu YY,Peng ZG,Feng ZB,Chen G

更新日期：2018-08-15 00:00:00

abstract：:The aim of the present research was to investigate the association between the BRAF mutation and papillary thyroid carcinoma (PTC), and further explore the relationship between the systemic inflammation response index (SIRI) and BRAF mutation in patients with PTC. The clinicopathological data were extracted from the p...

journal_title：American journal of translational research

authors： Xie H,Wei B,Shen H,Gao Y,Wang L,Liu H

更新日期：2018-08-15 00:00:00

abstract：:Exosomes released from mesenchymal stem cells (MSCs) have an anti-inflammatory effect and can repair tissue injuries. Ubiquitination plays an important role in the regulation of various biological functions, including the regulation of inflammation. However, it remains unknown whether exosomes from human umbilical cor...

journal_title：American journal of translational research

authors： Wu Y,Qiu W,Xu X,Kang J,Wang J,Wen Y,Tang X,Yan Y,Qian H,Zhang X,Xu W,Mao F

更新日期：2018-07-15 00:00:00

abstract：:Chronic kidney disease (CKD) results in various central nervous systems (CNS) disorders including cognitive dysfunction, depression, anxiety, movement disorders, seizures and encephalopathy. Uremic retention products, oxidative stress, inflammation and impaired blood-brain barrier have been implicated as the major med...

journal_title：American journal of translational research

authors： Jing W,Jabbari B,Vaziri ND

更新日期：2018-07-15 00:00:00

abstract：:[This corrects the article on p. 1295 in vol. 10, PMID: 29887946.]. ...

journal_title：American journal of translational research

authors： Lan D,Wang L,He R,Ma J,Bin Y,Chi X,Chen G,Cai Z

更新日期：2018-07-15 00:00:00

abstract：BACKGROUND:Circular RNAs (circRNAs) represent a class of non-coding RNAs that are emerging as important regulators during tumorigenesis and provide potential targets for cancer intervention. However, the expression profiles and functions of circRNAs in hepatocellular carcinoma (HCC) have not been completely clarified. ...

journal_title：American journal of translational research

authors： Cai H,Hu B,Ji L,Ruan X,Zheng Z

更新日期：2018-06-15 00:00:00

abstract：:In this study, we investigated the biological function of pyruvate kinase M2 (PKM2) and its regulation by deregulated microRNAs (miRNAs) in thyroid cancer (TC). The mRNA and protein expression of PKM2 was examined by quantitative reverse transcription PCR and western blot. The biological role of PKM2 was demonstrated ...

journal_title：American journal of translational research

authors： Yu G,Sun W,Shen Y,Hu Y,Liu H,Li W,Wang Y

更新日期：2018-06-15 00:00:00

abstract：:Although an increasing number of findings have proven that glutathione peroxidase 3 (GPX3) is methylated and down-regulated in various cancers, the underlying mechanism of its occurrence in esophageal squamous cell carcinoma (ESCC) remains unknown. In the present study, we found that the methylation rate in advanced c...

journal_title：American journal of translational research

authors： Zhu X,Wang J,Li L,Deng L,Wang J,Liu L,Zeng R,Wang Q,Zheng Y

更新日期：2018-06-15 00:00:00

abstract：:Background: Mitochondrial flashes (mitoflashes) are transient signals from transient bursts of reactive oxygen species (ROS) and changes in pH that occur in certain physiological or pathological conditions. Mitoflashes are closely related to metabolism, cell differentiation, stress response, diseases, and aging. Sepsi...

journal_title：American journal of translational research

authors： Chen W,Luo S,Xie P,Hou T,Yu T,Fu X

更新日期：2018-05-15 00:00:00

abstract：:Focal liver lesions (FLLs) include a variety of benign and malignant tumors, and are usually differential diagnosed by ultrasonography. However, traditional two-dimensional contrast-enhanced ultrasound (2D-CEUS) can evaluate a single slice of a lesion. It cannot fully display perfusion of a lesion and the relationship...

journal_title：American journal of translational research

authors： Lu Y,Liu B,Zheng Y,Luo J,Zhang X,Huang G,Xie X,Ye J,Wang W,Liu X,Xie X

更新日期：2018-05-15 00:00:00

abstract：:This study tested the hypothesis that healthy adipose-derived mesenchymal stem cell (ADMSC)-derived exosomes (HMSCEXO) and apoptotic (A) (induced by 12 h hypoxia/12 h starvation)-ADMSC-derived exosomes (AMSCEXO) were comparably effective at alleviating sepsis syndrome [SS; induced by cecal-ligation and puncture (CLP)]...

journal_title：American journal of translational research

authors： Chang CL,Sung PH,Chen KH,Shao PL,Yang CC,Cheng BC,Lin KC,Chen CH,Chai HT,Chang HW,Yip HK,Chen HH

更新日期：2018-04-15 00:00:00

abstract：:MicroRNAs (miRNAs) are involved in the development and progression of lung cancer. MicroRNA-101 (miR-101) displays crucial properties in non-small cell lung cancer (NSCLC) by negatively regulating cell proliferation and invasion, but the underlying molecular mechanisms remain largely unknown. In this study, we found t...

journal_title：American journal of translational research

authors： Han L,Chen W,Xia Y,Song Y,Zhao Z,Cheng H,Jiang T

更新日期：2018-04-15 00:00:00

abstract：:YM155 (Sepantronium bromide) is a potent small molecule inhibitor of survivin by suppression of survivin expression and shows the promising anticancer activity in many types of cancers. Docetaxel (Taxotere®) is a member of the taxane drugs used in the treatment of a number of cancers in clinic. Despite the therapeutic...

journal_title：American journal of translational research

authors： Hou LJ,Huang XX,Xu LN,Zhang YY,Zhao N,Ou RY,Li WF,Zhang WJ,Jiang QW,Yang Y,Wei MN,Huang JR,Wang K,Yuan ML,Xing ZH,Shi Z,Yan XJ

更新日期：2018-03-15 00:00:00